Elastage ECM™ "Extra Cellular Matrix Extract" contains Phytotherapeutic Extracts of Paeonia lactiflora, Antheum graveolens, Camellia seneisis, Vitiis vineferia, Curcuma longa and Cinnamomum vera.

The principal action of Elastage ECM is to stimulate the growth of elastin and strengthen the flexibility of the Extra Cellular Matrix (ECM). Elastic fibers, composed of an elastin core (90%) surrounded by fibrillin-rich microfibrils (10%),are essential extracellular matrix (ECM) macromolecules endowing extensible tissues with critical mechanical properties such as resilience, flexibility, and elasticity. The cross-linking theory of aging statesthat aging results from the accumulation of intra-intermolecular crosslinks between molecules with slow turnovers, such as collagen and elastin of the extracellular matrix (ECM). These crosslinks affect the physical properties of the ECM (stiffness) which causes cell dysfunction and ossification of the human physiology. There also exist adducts which may cause inflammation via activation of the receptor for advanced glycation end products (AGE). ECM aging might be even more important than cellular aging since cells have effective mechanisms to repair or remove damaged proteins and organelles. It was shown that cells in a proper environment could live significantly longer than the maximal lifespan of the animal. For example, mouse erythropoietic stem cells being serially transplanted to younger mice could live more than 3000 days, which is almost 3 times higher than maximal longevity of this animal. The extracellular matrix is mostly comprised of collagen and elastin. Both proteins are extremely longlived. Elastin is a highly stable molecule with longevity comparable with the human lifespan and any proteolytic damage that does occur with age and disease is essentially irreparable. The long life of these proteins makes them extremely susceptible to modifications such as glycation, and carbonylation. Mineralization, and glycation reduce the sensitivity of collagen to metalloproteinases (MMPs), increasing its susceptibility to crosslink and adduct formation. Since elastogenesis is restricted to fetal development and infancy, the elastin content of tissues (especially, vessel walls) decreases with time. The decrease in elastin, in turn, increases collagen content and ECM stiffness because collagen has a higher elastic modulus. Increased stiffness is a causative factor of many age-related diseases such as hypertension, and atherosclerosis. The decrease in elastin content puts the upper limit on the functioning of cardiovascular and pulmonary systems and this limit is estimated to be about 100–120 years for humans.